Gene Therapy and Tissue Engineering in Orthopaedic and by Christian Lattermann, Freddie H. Fu (auth.), Johnny Huard,

By Christian Lattermann, Freddie H. Fu (auth.), Johnny Huard, Freddie H. Fu (eds.)

This booklet has been written according to the numerous physicians and scien­ tists engaged on the improvement of organic techniques to supplying remedies for lots of orthopaedic problems in addition to to bettering the therapeutic of many tissues of the musculoskeletal process. the 1st objective of this publication is to make the language suitable among the bench scientist and the clinician operating in orthopaedic and activities medication for you to disguise particular components of the orthopaedic self-discipline the place the therapy might be stronger and/or replaced by means of the developments in molecular drugs. developments in molecular biology, which surround the examine of the genetic foundation of sickness, have produced new diagnostic tools and drug remedies for genetic illnesses and purchased problems. the expansion within the knowing of human genetics has additionally ended in the initiation of many human gene treatment experiments. even supposing many authorized healing medical trials utilizing this new know-how were played within the final ten years, the 1st medical trial utilizing this expertise within the quarter of orthopaedics used to be played on the collage of Pittsburgh.

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Gene Therapy and Tissue Engineering in Orthopaedic and Sports Medicine

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Conversion of mdx myofibers from dystrophin negative to positive by injection of normal myoblasts. Nature 337:176-9. , Priuchnic, R, and Huard, I 1998. Development of approaches to improve cell survival in Myoblast Transfer Therapy. J Cell Bioi 142(5):1257-67. , and Mandell, IL. 1992. Adenovirus as an expression vector in muscle cells in vivo. Proc Natl Acad Sci USA 89: 2581-4. S. L. 1996. Over expression of the type-1 insulin-like growth factor receptor increases ligand dependent proliferation and differentiation in bovine skeletal myogenic cultures.

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